FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements and to somatic mutations in several neoplasia. Recently, low levels of CCDC6 pr...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Morra, Francesco, Luise, Chiara, Merolla, Francesco, Poser, Ina, Visconti, Roberta, Ilardi, Gennaro, Paladino, Simona, Inuzuka, Hiroyuki, Guggino, Gianluca, Monaco, Roberto, Colecchia, David, Monaco, Guglielmo, Cerrato, Aniello, Chiariello, Mario, Denning, Krista, Claudio, Pier Paolo, Staibano, Stefania, Celetti, Angela
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494967/
https://ncbi.nlm.nih.gov/pubmed/25885523
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires