FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements and to somatic mutations in several neoplasia. Recently, low levels of CCDC6 pr...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Morra, Francesco, Luise, Chiara, Merolla, Francesco, Poser, Ina, Visconti, Roberta, Ilardi, Gennaro, Paladino, Simona, Inuzuka, Hiroyuki, Guggino, Gianluca, Monaco, Roberto, Colecchia, David, Monaco, Guglielmo, Cerrato, Aniello, Chiariello, Mario, Denning, Krista, Claudio, Pier Paolo, Staibano, Stefania, Celetti, Angela
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494967/
https://ncbi.nlm.nih.gov/pubmed/25885523
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items