Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enh...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Shen, Ying, Li, Jie, Nitta, Masayuki, Futalan, Diahnn, Steed, Tyler, Treiber, Jeffrey M., Taich, Zack, Stevens, Deanna, Wykosky, Jill, Chen, Hong-Zhuan, Carter, Bob S., Becher, Oren J., Kennedy, Richard, Esashi, Fumiko, Sarkaria, Jann N., Furnari, Frank B., Cavenee, Webster K., Desai, Arshad, Chen, Clark C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494902/
https://ncbi.nlm.nih.gov/pubmed/26059434
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