Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.

Transgenic (Tg) mice were constructed that express a chimeric prion protein (PrP) in which a segment of mouse (Mo) PrP was replaced with the corresponding human (Hu) PrP sequence. The chimeric PrP, designated MHu2MPrP, differs from MoPrP by 9 amino acids between residues 96 and 167. All of the Tg(MH...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Telling, G C, Scott, M, Hsiao, K K, Foster, D, Yang, S L, Torchia, M, Sidle, K C, Collinge, J, DeArmond, S J, Prusiner, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9936
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