Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.

Transgenic (Tg) mice were constructed that express a chimeric prion protein (PrP) in which a segment of mouse (Mo) PrP was replaced with the corresponding human (Hu) PrP sequence. The chimeric PrP, designated MHu2MPrP, differs from MoPrP by 9 amino acids between residues 96 and 167. All of the Tg(MH...

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Autori principali: Telling, G C, Scott, M, Hsiao, K K, Foster, D, Yang, S L, Torchia, M, Sidle, K C, Collinge, J, DeArmond, S J, Prusiner, S B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC44932/
https://ncbi.nlm.nih.gov/pubmed/7937921
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