Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.

Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from experimental murine scrapie; these mice were designated Tg(MoPrP-P101L)H. Brain homogenates from Tg(MoPrP-P1...

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Dettagli Bibliografici
Autori principali: Hsiao, K K, Groth, D, Scott, M, Yang, S L, Serban, H, Rapp, D, Foster, D, Torchia, M, Dearmond, S J, Prusiner, S B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC44760/
https://ncbi.nlm.nih.gov/pubmed/7916462
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