Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs

Determining the mechanism of gene function is greatly enhanced using conditional mutagenesis. However, generating engineered conditional alleles is inefficient and has only been widely used in mice. Importantly, multiplex conditional mutagenesis requires extensive breeding. Here we demonstrate a sys...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Yin, Linlin, Maddison, Lisette A., Li, Mingyu, Kara, Nergis, LaFave, Matthew C., Varshney, Gaurav K., Burgess, Shawn M., Patton, James G., Chen, Wenbiao
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2015
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492370/
https://ncbi.nlm.nih.gov/pubmed/25855067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.176917
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