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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/ https://ncbi.nlm.nih.gov/pubmed/26080442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112 |
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