Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Nan, Xiaolin, Tamgüney, Tanja M., Collisson, Eric A., Lin, Li-Jung, Pitt, Cameron, Galeas, Jacqueline, Lewis, Sophia, Gray, Joe W., McCormick, Frank, Chu, Steven
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2015
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/
https://ncbi.nlm.nih.gov/pubmed/26080442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112
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