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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/ https://ncbi.nlm.nih.gov/pubmed/26080442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112 |
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