Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nan, Xiaolin, Tamgüney, Tanja M., Collisson, Eric A., Lin, Li-Jung, Pitt, Cameron, Galeas, Jacqueline, Lewis, Sophia, Gray, Joe W., McCormick, Frank, Chu, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/
https://ncbi.nlm.nih.gov/pubmed/26080442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112
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