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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Nan, Xiaolin, Tamgüney, Tanja M., Collisson, Eric A., Lin, Li-Jung, Pitt, Cameron, Galeas, Jacqueline, Lewis, Sophia, Gray, Joe W., McCormick, Frank, Chu, Steven
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/
https://ncbi.nlm.nih.gov/pubmed/26080442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112
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