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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/ https://ncbi.nlm.nih.gov/pubmed/26080442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112 |
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