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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Proc Natl Acad Sci U S A |
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Κύριοι συγγραφείς: | , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
National Academy of Sciences
2015
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/ https://ncbi.nlm.nih.gov/pubmed/26080442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112 |
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