Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Nan, Xiaolin, Tamgüney, Tanja M., Collisson, Eric A., Lin, Li-Jung, Pitt, Cameron, Galeas, Jacqueline, Lewis, Sophia, Gray, Joe W., McCormick, Frank, Chu, Steven
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491781/
https://ncbi.nlm.nih.gov/pubmed/26080442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509123112
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