Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension

Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin-converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase expression is under the control of a tetracycline (doxycycline,...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Regul Integr Comp Physiol
Huvudupphovsmän: Garcia, Victor, Joseph, Gregory, Shkolnik, Brian, Ding, Yan, Zhang, Frank Fan, Gotlinger, Katherine, Falck, John R., Dakarapu, Rambabu, Capdevila, Jorge H., Bernstein, Kenneth E., Schwartzman, Michal Laniado
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2015
Ämnen:
Cardiovascular and Renal Integration
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491537/
https://ncbi.nlm.nih.gov/pubmed/25924878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00039.2015
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