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20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding

Increased vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, promotes vascular dysfunction, injury, and hypertension that is dependent, in part, on the renin angiotensin system (RAS). We have shown that, in human microvascular endothelial cells, 20-HET...

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書目詳細資料
發表在:J Pharmacol Exp Ther
Main Authors: Garcia, Victor, Shkolnik, Brian, Milhau, Laura, Falck, John R., Schwartzman, Michal Laniado
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767392/
https://ncbi.nlm.nih.gov/pubmed/26699146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229377
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