20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding

Increased vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, promotes vascular dysfunction, injury, and hypertension that is dependent, in part, on the renin angiotensin system (RAS). We have shown that, in human microvascular endothelial cells, 20-HET...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Garcia, Victor, Shkolnik, Brian, Milhau, Laura, Falck, John R., Schwartzman, Michal Laniado
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
Schlagworte:
Cellular and Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767392/
https://ncbi.nlm.nih.gov/pubmed/26699146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229377
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