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Attenuation of cardiac dysfunction in polymicrobial sepsis by microRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression

Cardiac dysfunction is a major consequence of sepsis/septic shock and contributes to the high mortality of sepsis. Innate and inflammatory responses mediated by Toll-like receptors (TLRs) play a critical role in sepsis-induced cardiac dysfunction. MicroRNA-146 was first identified as a negative regu...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Gao, Ming, Wang, Xiaohui, Zhang, Xia, Ha, Tuanzhu, Ma, He, Liu, Li, Kalbfleisch, John H., Gao, Xiang, Kao, Race L., Williams, David L., Li, Chuanfu
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490963/
https://ncbi.nlm.nih.gov/pubmed/26048146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403155
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