MicroRNA-125b Prevents Cardiac Dysfunction in Polymicrobial Sepsis by Targeting TRAF6-Mediated Nuclear Factor κB Activation and p53-Mediated Apoptotic Signaling

Background. This study examined the effect of microRNA-125b (miR-125b) on sepsis-induced cardiac dysfunction. Methods. Mouse hearts were transfected with lentivirus expressing miR-125b (LmiR-125b) 7 days before cecal ligation and puncture (CLP)–induced sepsis. Cardiac function was examined by echoca...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Ma, He, Wang, Xiaohui, Ha, Tuanzhu, Gao, Ming, Liu, Li, Wang, Ruitao, Yu, Kaijiang, Kalbfleisch, John H., Kao, Race L., Williams, David L., Li, Chuanfu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144735/
https://ncbi.nlm.nih.gov/pubmed/27683819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw449
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