TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism

Myocardial dysfunction is a major consequence of septic shock and contributes to the high mortality of sepsis. In the present study, we examined the effect of Toll-like receptor 2 (TLR2) ligands, peptidoglycan (PGN), and Pam3CSK4 (Pam3) on cardiac function in cecal ligation and puncture (CLP)-induce...

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Main Authors: Ha, Tuanzhu, Lu, Chen, Liu, Li, Hua, Fang, Hu, Yulong, Kelley, Jim, Singh, Krishna, Kao, Race L., Kalbfleisch, John, Williams, David L., Gao, Xiang, Li, Chuanfu
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2010
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838554/
https://ncbi.nlm.nih.gov/pubmed/20061538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01109.2009
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