Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis

Phosphoinositide-3-kinase (PI3K)/Akt dependent signaling has been shown to improve outcome in sepsis/septic shock. There is also ample evidence that PI3K/Akt dependent signaling plays a crucial role in maintaining normal cardiac function. We hypothesized that PI3K/Akt signaling may ameliorate septic...

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Autori principali: Li, Chuanfu, Hua, Fang, Ha, Tuanzhu, Singh, Krishna, Lu, Chen, Kalbfleisch, John, Breuel, Kevin F., Ford, Tiffany, Kao, Race L., Gao, Ming, Ozment, Tammy R., Williams, David L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446980/
https://ncbi.nlm.nih.gov/pubmed/23028587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044712
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