Overexpression of mutant HSP27 causes axonal neuropathy in mice

BACKGROUND: Mutations in heat shock 27 kDa protein 1 (HSP27 or HSPB1) cause distal hereditary motor neuropathy (dHMN) or Charcot-Marie-Tooth disease type 2 F (CMT2F) according to unknown factors. Mutant HSP27 proteins affect axonal transport by reducing acetylated tubulin. RESULTS: We generated a tr...

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Bibliografiske detaljer
Udgivet i:J Biomed Sci
Main Authors: Lee, Jinho, Jung, Sung-Chul, Joo, Jaesoon, Choi, Yu-Ri, Moon, Hyo Won, Kwak, Geon, Yeo, Ha Kyung, Lee, Ji-Su, Ahn, Hye-Jee, Jung, Namhee, Hwang, Sunhee, Rheey, Jingeun, Woo, So-Youn, Kim, Ji Yon, Hong, Young Bin, Choi, Byung-Ok
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490621/
https://ncbi.nlm.nih.gov/pubmed/26141737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-015-0154-y
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