HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the potential therapeutic effect o...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Kim, Ji-Yon, Woo, So-Youn, Hong, Young Bin, Choi, Heesun, Kim, Jisoo, Choi, Hyunjung, Mook-Jung, Inhee, Ha, Nina, Kyung, Jangbeen, Koo, Soo Kyung, Jung, Sung-Chul, Choi, Byung-Ok
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220520/
https://ncbi.nlm.nih.gov/pubmed/28105056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9475981
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