Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

BACKGROUND: Reduction or inhibition of histone deacetylase 6 (HDAC6) has been shown to rescue memory in mouse models of Alzheimer’s disease (AD) and is recently being considered a possible therapeutic strategy. However, the restoring mechanism of HDAC6 inhibition has not been fully understood. METHO...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Choi, Heesun, Kim, Haeng Jun, Kim, Jisoo, Kim, Soohyun, Yang, Jinhee, Lee, Wonik, Park, Yeonju, Hyeon, Seung Jae, Lee, Dong-Sup, Ryu, Hoon, Chung, Junho, Mook-Jung, Inhee
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330132/
https://ncbi.nlm.nih.gov/pubmed/28241840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0164-1
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