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HOMEOSTATIC REGULATION OF KCC2 ACTIVITY BY THE ZINC RECEPTOR mZnR/GPR39 DURING SEIZURES

The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic seizures. We previously demonstrated that synaptic activation of mZnR/GPR39 enhances inhibitory drive in the hippocampus by upregulating neuronal K(+)/Cl(−...

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Publicado en:Neurobiol Dis
Autores principales: Gilad, David, Shorer, Sharon, Ketzef, Maya, Friedman, Alon, Sekler, Israel, Aizenman, Elias, Hershfinkel, Michal
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490144/
https://ncbi.nlm.nih.gov/pubmed/25562657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.12.020
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