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The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis

Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We show that the zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression...

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Bibliographic Details
Published in:Philos Trans R Soc Lond B Biol Sci
Main Authors: Sunuwar, Laxmi, Medini, Michal, Cohen, Limor, Sekler, Israel, Hershfinkel, Michal
Format: Artigo
Language:Inglês
Published: The Royal Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938021/
https://ncbi.nlm.nih.gov/pubmed/27377730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2015.0420
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