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The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis
Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We show that the zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression...
Shranjeno v:
| izdano v: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Royal Society
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938021/ https://ncbi.nlm.nih.gov/pubmed/27377730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2015.0420 |
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