Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important mechani...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1994
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937876/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9700 |
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