Role of transforming growth factor-α in von Hippel– Lindau (VHL)(−/−) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL(−/−) RCC). Loss of VHL protein function is associated with constitutive expression of mRNAs encoding hypoxia-inducible proteins, such as vascular endothelial...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	de Paulsen, Natalie, Brychzy, Alexander, Fournier, Marie-Christine, Klausner, Richard D., Gnarra, James R., Pause, Arnim, Lee, Stephen
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29266/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11171960/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.031587498
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