Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important me...

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Detaylı Bibliyografya
Asıl Yazarlar: Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, Samid, D, Duan, D S, Gnarra, J R, Linehan, W M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1994
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC44884/
https://ncbi.nlm.nih.gov/pubmed/7937876
Etiketler: Etiketle
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