Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important mechani...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, Samid, D, Duan, D S, Gnarra, J R, Linehan, W M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937876/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9700
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