Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

Nrf2 appears to be a critical regulator of diabetes in rodents. However, the underlying mechanisms as well as the clinical relevance of the Nrf2 signaling in human diabetes remain to be fully understood. Herein, we report that islet expression of Nrf2 is upregulated at an earlier stage of diabetes i...

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Detaylı Bibliyografya
Yayımlandı:FEBS Lett
Asıl Yazarlar: Li, Wenjuan, Wu, Weiwei, Song, Haibo, Wang, Fang, Li, Huanjie, Chen, Li, Lai, Yimu, Janicki, Joseph S., Ward, Keith W., Meyer, Colin J., Wang, Xing Li, Tang, Dongqi, Cui, Taixing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486285/
https://ncbi.nlm.nih.gov/pubmed/24815692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.04.046
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