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Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody
Bispecific antibodies (BsAbs) have proven highly efficient T cell recruiters for cancer immunotherapy by virtue of one tumor antigen-reactive single chain variable fragment (scFv) and another that binds CD3. In order to enhance the antitumor potency of these tandem scFv BsAbs (tsc-BsAbs), we exploit...
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| Publié dans: | Oncoimmunology |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485828/ https://ncbi.nlm.nih.gov/pubmed/26137406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.989776 |
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