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Silencing Fc domains in T Cell–Engaging Bispecific Antibodies Improves T-Cell Trafficking and Antitumor Potency
Bispecific antibodies (BsAbs) that engage T cells bind to tumor cells via a tumor-associated antigen and to T cells through surface CD3. BsAbs have promising antitumor properties in vivo. Here we describe the effects of Fc silencing on BsAbs-driven T-cell trafficking to solid tumors. We used BsAbs d...
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| Publié dans: | Cancer Immunol Res |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7398503/ https://ncbi.nlm.nih.gov/pubmed/31615814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0121 |
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