High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort

RAS and BRAF mutations impact treatment and prognosis of metastatic colorectal cancer patients (mCRC), but the knowledge is based on trial patients usually not representative for the general cancer population. Patient characteristics, treatment and efficacy according to KRAS, BRAF and MSI status wer...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sorbye, Halfdan, Dragomir, Anca, Sundström, Magnus, Pfeiffer, Per, Thunberg, Ulf, Bergfors, Monica, Aasebø, Kristine, Eide, Geir Egil, Ponten, Fredrik, Qvortrup, Camilla, Glimelius, Bengt
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484806/
https://ncbi.nlm.nih.gov/pubmed/26121270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131046
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