Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

Murine double minute-2 (MDM2), an E3 ligase that regulates the cell cycle and inflammation, is highly expressed in podocytes. In podocyte injury, MDM2 drives podocyte loss by mitotic catastrophe, but the function of MDM2 in resting podocytes has not been explored. Here, we investigated the effects o...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Main Authors: Thomasova, Dana, Bruns, Hauke A., Kretschmer, Victoria, Ebrahim, Martrez, Romoli, Simone, Liapis, Helen, Kotb, Ahmed M., Endlich, Nicole, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2015
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483582/
https://ncbi.nlm.nih.gov/pubmed/25349197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040345
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