Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

Murine double minute-2 (MDM2), an E3 ligase that regulates the cell cycle and inflammation, is highly expressed in podocytes. In podocyte injury, MDM2 drives podocyte loss by mitotic catastrophe, but the function of MDM2 in resting podocytes has not been explored. Here, we investigated the effects o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Thomasova, Dana, Bruns, Hauke A., Kretschmer, Victoria, Ebrahim, Martrez, Romoli, Simone, Liapis, Helen, Kotb, Ahmed M., Endlich, Nicole, Anders, Hans-Joachim
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2015
Teme:
Brief Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483582/
https://ncbi.nlm.nih.gov/pubmed/25349197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040345
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