Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

Murine double minute-2 (MDM2), an E3 ligase that regulates the cell cycle and inflammation, is highly expressed in podocytes. In podocyte injury, MDM2 drives podocyte loss by mitotic catastrophe, but the function of MDM2 in resting podocytes has not been explored. Here, we investigated the effects o...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Thomasova, Dana, Bruns, Hauke A., Kretschmer, Victoria, Ebrahim, Martrez, Romoli, Simone, Liapis, Helen, Kotb, Ahmed M., Endlich, Nicole, Anders, Hans-Joachim
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2015
Fag:
Brief Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483582/
https://ncbi.nlm.nih.gov/pubmed/25349197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040345
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