CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism

Insufficient podocyte regeneration after injury is a central pathomechanism of glomerulosclerosis and chronic kidney disease. Podocytes constitutively secrete the chemokine CXCL12, which is known to regulate homing and activation of stem cells; hence we hypothesized a similar effect of CXCL12 on pod...

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Publié dans:Kidney Int
Auteurs principaux: Romoli, Simone, Angelotti, Maria Lucia, Antonelli, Giulia, Kumar VR, Santhosh, Mulay, Shrikant R., Desai, Jyaysi, Anguiano Gomez, Lidia, Thomasova, Dana, Eulberg, Dirk, Klussmann, Sven, Melica, Maria Elena, Conte, Carolina, Lombardi, Duccio, Lasagni, Laura, Anders, Hans-Joachim, Romagnani, Paola
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251974/
https://ncbi.nlm.nih.gov/pubmed/30385042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.08.013
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