CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism

Insufficient podocyte regeneration after injury is a central pathomechanism of glomerulosclerosis and chronic kidney disease. Podocytes constitutively secrete the chemokine CXCL12, which is known to regulate homing and activation of stem cells; hence we hypothesized a similar effect of CXCL12 on pod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Kidney Int
Prif Awduron: Romoli, Simone, Angelotti, Maria Lucia, Antonelli, Giulia, Kumar VR, Santhosh, Mulay, Shrikant R., Desai, Jyaysi, Anguiano Gomez, Lidia, Thomasova, Dana, Eulberg, Dirk, Klussmann, Sven, Melica, Maria Elena, Conte, Carolina, Lombardi, Duccio, Lasagni, Laura, Anders, Hans-Joachim, Romagnani, Paola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251974/
https://ncbi.nlm.nih.gov/pubmed/30385042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.08.013
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