Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

Murine double minute-2 (MDM2), an E3 ligase that regulates the cell cycle and inflammation, is highly expressed in podocytes. In podocyte injury, MDM2 drives podocyte loss by mitotic catastrophe, but the function of MDM2 in resting podocytes has not been explored. Here, we investigated the effects o...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Thomasova, Dana, Bruns, Hauke A., Kretschmer, Victoria, Ebrahim, Martrez, Romoli, Simone, Liapis, Helen, Kotb, Ahmed M., Endlich, Nicole, Anders, Hans-Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2015
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483582/
https://ncbi.nlm.nih.gov/pubmed/25349197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040345
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