MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury

Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation. MDM2 is highly expressed in the unchallenged tubular epi...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Thomasova, Dana, Ebrahim, Martrez, Fleckinger, Kristina, Li, Moying, Molnar, Jakob, Popper, Bastian, Liapis, Helen, Kotb, Ahmed M, Siegerist, Florian, Endlich, Nicole, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260907/
https://ncbi.nlm.nih.gov/pubmed/27882940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.390
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