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MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury
Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation. MDM2 is highly expressed in the unchallenged tubular epi...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Death Dis |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5260907/ https://ncbi.nlm.nih.gov/pubmed/27882940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.390 |
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