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Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork
Eukaryotes use distinct polymerases for leading- and lagging-strand replication, but how they target their respective strands is uncertain. We reconstituted Saccharomyces cerevisiae replication forks and found that CMG helicase selects polymerase (Pol) ε to the exclusion of Pol δ on the leading stra...
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| Udgivet i: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482249/ https://ncbi.nlm.nih.gov/pubmed/24997598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2851 |
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