Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

Pak1 plays an important role in various cellular processes, including cell motility, polarity, survival and proliferation. To date, its role in atherogenesis has not been explored. Here we report the effect of Pak1 on atherogenesis using atherosclerosis-prone apolipoprotein E-deficient (ApoE(−/−)) m...

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Udgivet i:Nat Commun
Main Authors: Singh, Nikhlesh K., Kotla, Sivareddy, Dyukova, Elena, Traylor Jr., James G., Orr, A. Wayne, Chernoff, Jonathan, Marion, Tony N., Rao, Gadiparthi N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480433/
https://ncbi.nlm.nih.gov/pubmed/26104863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8450
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