Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

Pak1 plays an important role in various cellular processes, including cell motility, polarity, survival and proliferation. To date, its role in atherogenesis has not been explored. Here we report the effect of Pak1 on atherogenesis using atherosclerosis-prone apolipoprotein E-deficient (ApoE(−/−)) m...

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Vydáno v:Nat Commun
Hlavní autoři: Singh, Nikhlesh K., Kotla, Sivareddy, Dyukova, Elena, Traylor Jr., James G., Orr, A. Wayne, Chernoff, Jonathan, Marion, Tony N., Rao, Gadiparthi N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480433/
https://ncbi.nlm.nih.gov/pubmed/26104863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8450
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