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Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

Pak1 plays an important role in various cellular processes, including cell motility, polarity, survival and proliferation. To date, its role in atherogenesis has not been explored. Here we report the effect of Pak1 on atherogenesis using atherosclerosis-prone apolipoprotein E-deficient (ApoE(−/−)) m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Singh, Nikhlesh K., Kotla, Sivareddy, Dyukova, Elena, Traylor Jr., James G., Orr, A. Wayne, Chernoff, Jonathan, Marion, Tony N., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480433/
https://ncbi.nlm.nih.gov/pubmed/26104863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8450
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