Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors

The cell of origin of the five subtypes (I-V) of germ cell tumors (GCTs) are assumed to be germ cells from different maturation stages. This is (potentially) reflected in their methylation status as fetal maturing primordial germ cells are globally demethylated during migration from the yolk sac to...

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Pubblicato in:PLoS One
Autori principali: Rijlaarsdam, Martin A., Tax, David M. J., Gillis, Ad J. M., Dorssers, Lambert C. J., Koestler, Devin C., de Ridder, Jeroen, Looijenga, Leendert H. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479500/
https://ncbi.nlm.nih.gov/pubmed/25859847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122146
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