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Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibilit...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lobo, João, Gillis, Ad J. M., Jerónimo, Carmen, Henrique, Rui, Looijenga, Leendert H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359418/
https://ncbi.nlm.nih.gov/pubmed/30634670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20020258
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