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Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion(1)
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible...
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| Pubblicato in: | J Lipid Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Biochemistry and Molecular Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4479334/ https://ncbi.nlm.nih.gov/pubmed/25954050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054882 |
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