Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion(1)

Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Wang, Yan, Gusarova, Viktoria, Banfi, Serena, Gromada, Jesper, Cohen, Jonathan C., Hobbs, Helen H.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479334/
https://ncbi.nlm.nih.gov/pubmed/25954050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054882
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