mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5

Homozygosity for a natural deletion variant of the HIV-coreceptor molecule CCR5, CCR5Δ32, confers resistance toward HIV infection. Allogeneic stem cell transplantation from a CCR5Δ32-homozygous donor has resulted in the first cure from HIV (‘Berlin patient’). Based thereon, genetic disruption of CCR...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Mock, Ulrike, Machowicz, Rafał, Hauber, Ilona, Horn, Stefan, Abramowski, Pierre, Berdien, Belinda, Hauber, Joachim, Fehse, Boris
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477672/
https://ncbi.nlm.nih.gov/pubmed/25964300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv469
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