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Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease

Phosphatase and tensin homolog (PTEN) is a lipid and protein phosphatase that antagonizes signaling by the phosphatidylinositol 3-kinase (PI3K)–AKT signaling pathway. The PTEN gene is a major tumor suppressor, with mutations of this gene occurring frequently in tumors of humans and mice. We have now...

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Veröffentlicht in:PLoS One
Hauptverfasser: Matsuzaki, Yuriko, Sakuma, Tetsushi, Yamamoto, Takashi, Saya, Hideyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650176/
https://ncbi.nlm.nih.gov/pubmed/29053747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186878
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