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Establishment of HRAS(G12V) Transgenic Medaka as a Stable Tumor Model for In Vivo Screening of Anticancer Drugs

Most targeted anticancer drugs have been identified by screening at the molecular or cellular level in vitro. However, many compounds selected by such costly and time-consuming screening do not prove effective against tumors in vivo. The development of anticancer drugs would thus be facilitated by t...

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Detalhes bibliográficos
Main Authors: Matsuzaki, Yuriko, Hosokai, Haru, Mizuguchi, Yukiyo, Fukamachi, Shoji, Shimizu, Atsushi, Saya, Hideyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544794/
https://ncbi.nlm.nih.gov/pubmed/23342156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054424
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