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Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction
The neurodegenerative disorder spinocerebellar ataxia type 7 (SCA7) is caused by a polyglutamine (polyQ) expansion in the ataxin-7 protein, categorizing SCA7 as one member of a large class of heritable neurodegenerative proteinopathies. Cleavage of ataxin-7 by the protease caspase-7 has been demonst...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476441/ https://ncbi.nlm.nih.gov/pubmed/25859008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv121 |
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